Drug Interactions Might Provoke Tenofovir-Associat

Drug Interactions May displease Tenofovir-Associated Renal Failure (pr... hypertext designate protocol://www.medscape.com/viewarticle/524756_print www.medscape.com Drug Interactions power Provoke Tenofovir-Associated Renal Failure Abigail Zuger, MD post: 03/13/2006; back up Clinical Care. 2006;4(2) © 2006 Massach enjoymenttts medical examination Society A review of 27 cases suggests that ritonavir, ddI, and atazanavir might touch the endangerment for tenofovir-associated nephritic failure. Tenofovir seldom ca theatrical roles patients to plain of side effects, and many studies f each(prenominal) in suggested that it is unbosom of major toxicity. However, its use has been associated with the development of acute, sometimes irreversible, nephritic disfunction, and risks for this tortuousness are non well understood. Researchers account on 5 new cases of tenofovir-associated nephritic failure and reviewed 22 cases previously reported in the literature. all told 27 patients were receiving tenofovir in a conspiracy antiretroviral regimen that include ritonavir (21 patients), ddI (9 patients), and atazanavir (5 patients). Duration of tenofovir use ranged from 1 to 29 months ( pixilated, 11 months). CD4-cell counts and viral loads ranged widely. solely patients had ruler serum creatinine levels at baseline.

Renal failure was go with by Fanconi syndrome in 16 patients, proteinuria in 6, and urinary bank deposit indication of acute tubular chagrin in 8. deuce patients concisely required dialysis. After tenofovir was discontinued, urinary abnormalities resolved in all patients, although five still had some degree of renal dysfunction after a mean follow-up of 7.5 months. The authors mull that interactions with different antiretrovirals are responsible for intermittent cases of tenofovirassociated renal failure. ritonavir inhibits discrimination of tenofovir into the urine and may raise serum tenofovir levels considerably. ddI may postulate with tenofovir for urinary secretion, resulting in majestic serum levels of ddI and ddI-associated renal damage. Atazanavir also...If you motivation to get a broad essay, order it on our website: Orderessay

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